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David J Kwiatkowski Selected Research

Phosphotransferases (Kinase)

11/2021RAF1 amplification drives a subset of bladder tumors and confers sensitivity to MAPK-directed therapeutics.
1/2021Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer.
1/2018RAS-MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR-MEK Blockade.
3/2016Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.
10/2015Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise.
1/2015Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target.
8/2013Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer.
4/2011Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin.
3/2002A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells.

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David J Kwiatkowski Research Topics

Disease

114Tuberous Sclerosis (Bourneville's Disease)
03/2024 - 03/2002
106Neoplasms (Cancer)
02/2024 - 03/2002
26Lymphangioleiomyomatosis (Lymphangiomyomatosis)
03/2023 - 08/2002
22Epilepsy (Aura)
11/2023 - 12/2002
20Angiomyolipoma
10/2023 - 10/2002
19Lung Neoplasms (Lung Cancer)
01/2023 - 12/2012
18Hamartoma
03/2023 - 03/2002
16Renal Cell Carcinoma (Grawitz Tumor)
01/2022 - 11/2010
13Intellectual Disability (Idiocy)
07/2022 - 07/2005
12Inborn Genetic Diseases (Disease, Hereditary)
07/2022 - 03/2002
12Seizures (Absence Seizure)
01/2022 - 09/2002
11Carcinogenesis
01/2021 - 07/2009
11Autistic Disorder (Autism)
01/2020 - 12/2002
10Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
02/2024 - 07/2004
10Urinary Bladder Neoplasms (Bladder Cancer)
12/2022 - 01/2013
8Angiofibroma
03/2023 - 04/2014
7Perivascular Epithelioid Cell Neoplasms
03/2024 - 02/2010
7Autism Spectrum Disorder
07/2022 - 05/2009
7Adenocarcinoma
03/2018 - 06/2013
6Carcinoma (Carcinomatosis)
03/2022 - 04/2014
6Astrocytoma (Pilocytic Astrocytoma)
01/2021 - 12/2004
6Cystadenoma
03/2015 - 10/2003
6Asthma (Bronchial Asthma)
09/2004 - 12/2002
5Lung Diseases (Lung Disease)
03/2023 - 04/2007
4Adenocarcinoma of Lung
01/2023 - 02/2015
4Disease Progression
01/2022 - 01/2014
4Cysts
01/2021 - 01/2014
3Neurodevelopmental Disorders
10/2021 - 10/2012
3Respiratory Insufficiency (Respiratory Failure)
11/2020 - 01/2014
3Neurologic Manifestations (Neurological Manifestations)
12/2019 - 01/2013
3Cardiomegaly (Heart Hypertrophy)
03/2015 - 05/2006
3Infantile Spasms (West Syndrome)
12/2011 - 07/2005
3Hemangioma (Angioma)
07/2009 - 03/2002
2Brain Neoplasms (Brain Tumor)
01/2021 - 11/2017
2Neoplasm Metastasis (Metastasis)
01/2020 - 10/2018
2Hydrocephalus (Hydrocephaly)
12/2019 - 01/2013
2Hypertension (High Blood Pressure)
12/2016 - 08/2008
2Leiomyoma (Uterine Fibroids)
10/2015 - 01/2014
2Brain Diseases (Brain Disorder)
01/2013 - 05/2008
2Neurocutaneous Syndromes (Phakomatoses)
11/2010 - 03/2010
2Chronic Obstructive Pulmonary Disease (COPD)
08/2004 - 01/2003
1Bites and Stings (Sting)
02/2024

Drug/Important Bio-Agent (IBA)

107trans-sodium crocetinate (crocetin)IBA
03/2024 - 03/2002
34Mechanistic Target of Rapamycin Complex 1IBA
11/2023 - 05/2008
32Sirolimus (Rapamycin)FDA Link
03/2024 - 09/2003
21TOR Serine-Threonine KinasesIBA
12/2015 - 10/2002
20lipoarabinomannan (LAM)IBA
03/2023 - 08/2002
18Proteins (Proteins, Gene)FDA Link
11/2022 - 08/2002
17MTOR InhibitorsIBA
11/2023 - 05/2008
11Biomarkers (Surrogate Marker)IBA
11/2023 - 10/2018
10DNA (Deoxyribonucleic Acid)IBA
02/2024 - 01/2003
9Tyrosine Kinase InhibitorsIBA
01/2023 - 06/2013
9Phosphotransferases (Kinase)IBA
11/2021 - 03/2002
8Tuberous Sclerosis Complex 2 ProteinIBA
01/2021 - 08/2002
7Immune Checkpoint InhibitorsIBA
02/2024 - 01/2020
6RNA (Ribonucleic Acid)IBA
01/2021 - 03/2016
5Interferon-gamma (Interferon, gamma)IBA
02/2024 - 10/2002
5atezolizumabIBA
12/2023 - 01/2018
5ErbB Receptors (EGF Receptor)IBA
01/2023 - 06/2013
5EverolimusFDA Link
01/2021 - 05/2008
5Tuberous Sclerosis Complex 1 ProteinIBA
01/2021 - 10/2002
4VigabatrinFDA Link
11/2023 - 01/2020
4Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
10/2020 - 03/2007
4Cell-Free Nucleic AcidsIBA
01/2020 - 01/2018
4NucleotidesIBA
01/2020 - 01/2009
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2016 - 09/2003
4Anaplastic Lymphoma KinaseIBA
02/2015 - 06/2013
3Cytostatic AgentsIBA
11/2022 - 10/2017
3MicroRNAs (MicroRNA)IBA
07/2022 - 10/2017
3PlatinumIBA
03/2022 - 04/2014
3ChromatinIBA
01/2021 - 04/2015
3ParaffinIBA
10/2020 - 01/2012
3NestinIBA
01/2019 - 11/2011
2osimertinibIBA
01/2024 - 11/2018
2Pemetrexed (MTA)FDA Link
11/2023 - 10/2023
2sapanisertibIBA
01/2022 - 05/2013
2Mitochondrial DNA (mtDNA)IBA
01/2022 - 09/2014
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
11/2021 - 01/2018
2Phenobarbital (Luminal)FDA Link
11/2021 - 10/2015
2Microphthalmia-Associated Transcription FactorIBA
01/2021 - 01/2017
2Formaldehyde (Formol)FDA Link
10/2020 - 12/2012
2Glutathione (Reduced Glutathione)IBA
11/2019 - 01/2018
2Codon (Codons)IBA
01/2019 - 11/2006
2VimentinIBA
12/2018 - 07/2014
2AntigensIBA
01/2018 - 03/2005
2Messenger RNA (mRNA)IBA
10/2017 - 03/2015
2Polycomb Repressive Complex 2IBA
01/2017 - 01/2017
2Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
10/2015 - 04/2015
2Estrogens (Estrogen)FDA Link
01/2014 - 03/2005
2Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
08/2013 - 08/2007
2Phosphatidylinositols (Phosphatidylinositol)IBA
03/2013 - 11/2010
2EndotoxinsIBA
12/2010 - 12/2002
2Atorvastatin (Lipitor)FDA Link
07/2009 - 10/2007
2Bronchodilator Agents (Bronchodilators)IBA
08/2004 - 08/2003
2Epidermal Growth Factor (EGF)IBA
07/2004 - 10/2003
1Glutamine (L-Glutamine)FDA Link
02/2024

Therapy/Procedure

40Therapeutics
11/2023 - 05/2004
5Immunotherapy
02/2024 - 12/2018
2Drug Therapy (Chemotherapy)
01/2015 - 04/2014
2Ligation
01/2013 - 01/2009